Regulation of microtubule polymerization or depolymerization

Across TCGA patient cohorts, RNA activity of the Regulation of microtubule polymerization or depolymerization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B, MAP1B_S1881, and MAP1B_S1016, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of microtubule polymerization or depolymerization activity versus MAP1B in LSCC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1B →	+1.017	+0.039	<.001	<.001	3	7
LSCC	MAP1B_S1881 →	+1.449	+0.047	<.001	<.001	3	7
LSCC	MAP1B_S1016 →	+1.231	+0.038	<.001	<.001	3	6
HNSC	MAP1B_S1427 →	+1.324	+0.065	<.001	<.001	3	6
LSCC	MAP1B_S1779 →	+1.488	+0.040	<.001	<.001	3	6
LSCC	MAP1B_S1965 →	+1.179	+0.041	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031110 vs MAP1B — LSCC

Explore this scatter interactively →