Regulation of microtubule polymerization or depolymerization

Across TCGA cell cohorts, RNA activity of the Regulation of microtubule polymerization or depolymerization pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA9, PLEKHA7, and ACSF2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANXA9 grouped by Regulation of microtubule polymerization or depolymerization-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ANXA9 →	+2.134	+0.302	<.001	<.001	3	6
URINARY_TRACT	PLEKHA7 →	+3.660	+0.379	.003	.005	3	5
PANCREAS	ACSF2 →	+1.401	+0.143	.008	.003	3	4
PANCREAS	SLC34A3 →	+0.460	+0.233	.003	.001	3	4
PANCREAS	B4GALT1 →	+1.067	+0.217	.001	<.001	3	4
LUNG_SCLC	VPS41 →	+0.492	+0.205	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANXA9 by Regulation of microtubule polymerization or depolymerization activity — OVARY

Explore this box plot interactively →