Microtubule polymerization or depolymerization

Across TCGA cell cohorts, RNA activity of the Microtubule polymerization or depolymerization pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL11, EPS8, and GSN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MRPL11 grouped by Microtubule polymerization or depolymerization-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MRPL11 →	-0.662	-0.204	<.001	.008	2	6
BLOOD_Leukemia	EPS8 →	+2.088	+0.273	<.001	<.001	3	5
URINARY_TRACT	GSN →	+2.656	+0.167	.004	.008	3	4
BONE	ERMP1 →	+1.168	+0.291	.003	.001	3	4
KIDNEY	LURAP1L →	+1.827	+0.201	.002	.008	3	4
BREAST	EPHA4 →	+1.974	+0.220	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MRPL11 by Microtubule polymerization or depolymerization activity — STOMACH

Explore this box plot interactively →