Microtubule polymerization or depolymerization

Across TCGA cell cohorts, RNA activity of the Microtubule polymerization or depolymerization pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STARD9, CLSPN, and KIF14, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule polymerization or depolymerization activity versus STARD9 in BREAST (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	STARD9 →	+1.406	+0.119	<.001	<.001	3	19
STOMACH	CLSPN →	+1.669	+0.097	<.001	.003	3	19
BLOOD_Lymphoma	KIF14 →	+1.384	+0.080	<.001	<.001	3	19
BONE	ZGRF1 →	+1.182	+0.105	<.001	<.001	3	19
SOFT_TISSUE	CCDC66 →	+0.884	+0.083	<.001	<.001	3	19
BONE	ARHGAP33 →	+2.026	+0.130	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031109 vs STARD9 — BREAST

Explore this scatter interactively →