Neuron projection regeneration

Across TCGA patient cohorts, RNA activity of the Neuron projection regeneration pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MRPS5, NOLC1_S538, and TLN2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron projection regeneration activity versus MRPS5 in OV (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MRPS5 →	-0.312	-0.040	.001	<.001	3	9
LSCC	NOLC1_S538 →	-0.568	-0.057	<.001	<.001	3	9
HNSC	TLN2 →	+0.504	+0.063	<.001	<.001	3	8
OV	MMP2 →	+0.839	+0.051	<.001	<.001	3	8
LUAD	PDLIM3 →	+0.331	+0.038	.001	<.001	3	8
LUAD	SERBP1 →	-0.208	-0.048	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031102 vs MRPS5 — OV

Explore this scatter interactively →