Neuron projection regeneration

Across TCGA cell cohorts, RNA activity of the Neuron projection regeneration pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE2G1, NUB1, and MRM3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBE2G1 grouped by Neuron projection regeneration-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UBE2G1 →	-1.116	-1.493	.002	<.001	3	3
BLOOD_Leukemia	NUB1 →	-1.183	-1.505	<.001	<.001	3	3
KIDNEY	MRM3 →	-0.822	-0.881	.006	.009	3	3
BLOOD_Leukemia	ZNF217 →	-1.096	-1.044	.004	.002	3	3
BLOOD_Leukemia	CHURC1 →	-0.660	-1.432	<.001	<.001	3	3
BONE	FIGNL2 →	-0.266	-1.221	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBE2G1 by Neuron projection regeneration activity — BLOOD_Leukemia

Explore this box plot interactively →