Neuron projection regeneration

Across TCGA cell cohorts, RNA activity of the Neuron projection regeneration pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RIPOR2, RIDA, and RALGPS2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron projection regeneration activity versus RIPOR2 in BLOOD_Leukemia (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RIPOR2 →	+2.076	+0.929	.002	.004	3	6
PANCREAS	RIDA →	-0.840	-0.290	.001	<.001	3	5
BLOOD_Lymphoma	RALGPS2 →	+3.686	+1.418	<.001	<.001	3	5
BLOOD_Leukemia	IL32 →	+3.126	+0.861	<.001	.001	3	5
BREAST	EEF1B2 →	-0.662	-0.536	.004	.007	3	4
LUNG_NSCLC_LUSC	AHDC1 →	+1.551	+0.363	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031102 vs RIPOR2 — BLOOD_Leukemia

Explore this scatter interactively →