Animal organ regeneration

Across TCGA patient cohorts, RNA activity of the Animal organ regeneration pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CEBPB, DDAH1, and FNDC3B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Animal organ regeneration activity versus CEBPB in BRCA (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CEBPB →	+0.407	+0.034	<.001	<.001	3	6
LUAD	DDAH1 →	-0.587	-0.062	<.001	<.001	3	6
GBM	FNDC3B →	+0.468	+0.047	<.001	<.001	3	6
GBM	GFPT2 →	+0.816	+0.046	<.001	.001	3	6
LUAD	IGF2BP1_S181 →	+1.933	+0.043	<.001	<.001	3	6
GBM	IKBIP →	+0.762	+0.050	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031100 vs CEBPB — BRCA

Explore this scatter interactively →