Animal organ regeneration

Across TCGA patient cohorts, RNA activity of the Animal organ regeneration pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIP13, HMGA1, and CD300E, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Animal organ regeneration activity versus TRIP13 in BRCA (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRIP13 →	+0.780	+0.236	.001	<.001	3	6
BRCA	HMGA1 →	+0.826	+0.210	.001	.002	3	5
GBM	CD300E →	+1.144	+0.225	<.001	<.001	3	5
GBM	AQP9 →	+1.128	+0.151	<.001	<.001	3	5
BRCA	SOD2 →	+0.749	+0.217	<.001	.003	3	5
GBM	TREM1 →	+1.057	+0.166	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031100 vs TRIP13 — BRCA

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