Animal organ regeneration

Across TCGA cell cohorts, RNA activity of the Animal organ regeneration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TDP2, MAPK13, and RIT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TDP2 grouped by Animal organ regeneration-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TDP2 →	+1.184	+0.321	.001	.003	2	6
BLOOD_Myeloma	MAPK13 →	+2.422	+0.380	.005	.009	2	6
LUNG_NSCLC_LUSC	RIT1 →	+1.780	+0.324	<.001	<.001	3	4
LUNG_NSCLC_LUSC	PAXBP1 →	+0.751	+0.220	.003	.006	3	4
LUNG_NSCLC_LUSC	TXNDC2 →	-0.276	-0.242	.002	.001	3	4
LUNG_NSCLC_LUSC	BRI3BP →	+1.020	+0.223	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TDP2 by Animal organ regeneration activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →