Animal organ regeneration

Across TCGA cell cohorts, RNA activity of the Animal organ regeneration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGDIB, SERINC2, and FAM214B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Animal organ regeneration activity versus ARHGDIB in LUNG_NSCLC_LUAD (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ARHGDIB →	-3.252	-0.223	<.001	.002	3	6
LUNG_NSCLC_LUAD	SERINC2 →	-2.039	-0.238	.001	<.001	3	5
LARGE_INTESTINE	FAM214B →	-0.956	-0.123	.002	.005	3	5
URINARY_TRACT	KLC3 →	-2.676	-0.414	.001	.002	3	5
OVARY	USP39 →	+0.480	+0.188	.004	.003	3	4
OVARY	USP13 →	+0.917	+0.166	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031100 vs ARHGDIB — LUNG_NSCLC_LUAD

Explore this scatter interactively →