Regeneration

Across TCGA patient cohorts, RNA activity of the Regeneration pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1R, C1S, and CTHRC1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regeneration activity versus C1R in OV (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	C1R →	+0.766	+0.043	<.001	<.001	3	8
BRCA	C1S →	+0.573	+0.028	<.001	<.001	3	8
COAD	CTHRC1 →	+1.072	+0.026	<.001	<.001	3	8
OV	FN1 →	+1.025	+0.040	<.001	<.001	3	8
OV	THBS2 →	+1.193	+0.037	<.001	<.001	3	7
BRCA	TIMP2 →	+0.683	+0.028	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031099 vs C1R — OV

Explore this scatter interactively →