Regeneration

Across TCGA patient cohorts, RNA activity of the Regeneration pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B4GALNT1, SLC2A6, and AK8, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regeneration activity versus B4GALNT1 in BRCA (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	B4GALNT1 →	+1.099	+0.300	.008	<.001	3	2
BRCA	SLC2A6 →	+2.083	+0.350	.005	.007	3	2
BRCA	AK8 →	-2.106	-0.363	<.001	.004	3	2
BRCA	KRT86 →	+3.056	+0.269	<.001	.005	3	2
BRCA	VIM-AS1 →	+2.410	+0.360	.008	.004	3	2
BRCA	CFAP58-DT →	+1.624	+0.269	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031099 vs B4GALNT1 — BRCA

Explore this scatter interactively →