Regeneration

Across TCGA cell cohorts, RNA activity of the Regeneration pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AAMP, C6orf52, and CHRNA10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AAMP grouped by Regeneration-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	AAMP →	+0.971	+0.225	<.001	<.001	3	4
CNS	C6orf52 →	+0.764	+0.162	.005	.001	3	4
LIVER	CHRNA10 →	+0.746	+0.265	.008	.007	3	4
OESOPHAGUS	GPNMB →	-3.730	-0.155	.008	.005	2	4
BLOOD_Leukemia	PRKX →	-0.825	-0.163	.004	.002	3	3
LARGE_INTESTINE	RPF1 →	-0.726	-0.200	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AAMP by Regeneration activity — BLOOD_Myeloma

Explore this box plot interactively →