Regeneration

Across TCGA cell cohorts, RNA activity of the Regeneration pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DIPK1A, LAMB3, and USP49, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regeneration activity versus DIPK1A in BLOOD_Leukemia (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DIPK1A →	+1.783	+0.219	<.001	<.001	3	6
LUNG_NSCLC_LUSC	LAMB3 →	-5.427	-0.214	.002	.003	3	5
BREAST	USP49 →	+0.990	+0.201	.001	<.001	3	5
LUNG_NSCLC_LUSC	UBE2R2 →	+0.930	+0.205	.006	.002	3	4
LUNG_NSCLC_LUSC	AREG →	-4.362	-0.223	.009	.003	3	4
LUNG_NSCLC_LUSC	ZBTB18 →	+1.565	+0.245	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031099 vs DIPK1A — BLOOD_Leukemia

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