Stress-activated protein kinase signaling cascade

Across TCGA patient cohorts, RNA activity of the Stress-activated protein kinase signaling cascade pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN4, PLEKHO2, and SORBS1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Stress-activated protein kinase signaling cascade activity versus SEPTIN4 in CCRCC (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SEPTIN4 →	+0.467	+0.036	<.001	<.001	3	9
OV	PLEKHO2 →	+0.336	+0.030	.004	.009	3	9
BRCA	SORBS1 →	+0.577	+0.028	<.001	<.001	3	9
OV	TBC1D2B →	+0.347	+0.035	.003	.001	3	9
LUAD	YME1L1 →	-0.380	-0.038	<.001	<.001	3	8
BRCA	CLPX →	-0.299	-0.026	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031098 vs SEPTIN4 — CCRCC

Explore this scatter interactively →