Stress-activated protein kinase signaling cascade

Across TCGA patient cohorts, RNA activity of the Stress-activated protein kinase signaling cascade pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUB1, STX17, and TFAP2A, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Stress-activated protein kinase signaling cascade activity versus NUB1 in COAD (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NUB1 →	+1.719	+0.629	.009	.009	3	1
COAD	STX17 →	+0.965	+0.629	<.001	.009	3	1
COAD	TFAP2A →	+1.510	+0.629	<.001	.009	3	1
COAD	PRDM8 →	+2.175	+0.629	<.001	.009	3	1
COAD	FCRL3 →	+1.035	+0.629	.001	.009	3	1
COAD	SLC16A11 →	+0.459	+0.629	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031098 vs NUB1 — COAD

Explore this scatter interactively →