Stress-activated protein kinase signaling cascade

Across TCGA cell cohorts, RNA activity of the Stress-activated protein kinase signaling cascade pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEUROG3, IFNA16, and TESK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NEUROG3 grouped by Stress-activated protein kinase signaling cascade-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NEUROG3 →	-0.228	-0.089	.001	<.001	2	5
BONE	IFNA16 →	-0.146	-0.103	.004	<.001	3	4
OESOPHAGUS	TESK1 →	-0.118	-0.094	.004	.004	3	4
LUNG_NSCLC_LUAD	PTGFR →	-0.140	-0.060	.001	.009	3	4
URINARY_TRACT	NMRK2 →	+0.343	+0.125	<.001	.001	3	3
BLOOD_Myeloma	RBM24 →	+0.347	+0.094	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NEUROG3 by Stress-activated protein kinase signaling cascade activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →