Stress-activated protein kinase signaling cascade

Across TCGA cell cohorts, RNA activity of the Stress-activated protein kinase signaling cascade pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are QSOX1, PAPSS2, and IKBIP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Stress-activated protein kinase signaling cascade activity versus QSOX1 in BONE (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	QSOX1 →	+1.730	+1.135	.005	.001	3	5
BONE	PAPSS2 →	+3.479	+1.388	<.001	.003	3	5
BONE	IKBIP →	+1.223	+1.405	.004	.003	3	4
BONE	DAB2 →	+2.618	+1.495	.006	<.001	3	4
CNS	AMMECR1L →	+0.463	+0.976	.001	<.001	3	4
LUNG_NSCLC_LUAD	MAPK1 →	+0.749	+0.582	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031098 vs QSOX1 — BONE

Explore this scatter interactively →