"Nuclear-transcribed mRNA catabolic process, deadenylation-independent decay"

Across TCGA patient cohorts, RNA activity of the "Nuclear-transcribed mRNA catabolic process, deadenylation-independent decay" pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DCP1B, UBA2, and RCOR3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Nuclear-transcribed mRNA catabolic process, deadenylation-independent decay" activity versus DCP1B in LSCC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DCP1B →	+0.282	+0.041	<.001	.002	3	6
LSCC	UBA2 →	+0.228	+0.048	.003	.001	3	6
HNSC	RCOR3 →	+0.425	+0.082	<.001	<.001	3	5
BRCA	TP53BP1 →	+0.266	+0.028	<.001	<.001	3	5
CCRCC	SMC3 →	+0.129	+0.038	.002	.001	3	5
CCRCC	GTF3C2 →	+0.119	+0.033	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031086 vs DCP1B — LSCC

Explore this scatter interactively →