"Nuclear-transcribed mRNA catabolic process, deadenylation-independent decay"

Across TCGA patient cohorts, RNA activity of the "Nuclear-transcribed mRNA catabolic process, deadenylation-independent decay" pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS28P4, NIP7, and EIF4BP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Nuclear-transcribed mRNA catabolic process, deadenylation-independent decay" activity versus RPS28P4 in OV (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RPS28P4 →	-1.146	-0.294	.006	.004	3	3
PDAC	NIP7 →	+0.261	+0.519	.002	.005	3	3
COAD	EIF4BP1 →	-0.229	-0.592	<.001	<.001	3	3
BRCA	MACROH2A2 →	+0.652	+0.373	<.001	.004	3	3
BRCA	ARHGAP32 →	-0.555	-0.479	.009	.001	3	3
BRCA	HMGB1P11 →	+0.333	+0.551	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031086 vs RPS28P4 — OV

Explore this scatter interactively →