"Nuclear-transcribed mRNA catabolic process, deadenylation-independent decay"

Across TCGA cell cohorts, RNA activity of the "Nuclear-transcribed mRNA catabolic process, deadenylation-independent decay" pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDC4, NOB1, and THAP11, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Nuclear-transcribed mRNA catabolic process, deadenylation-independent decay" activity versus EDC4 in BLOOD_Leukemia (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EDC4 →	+0.777	+0.921	<.001	<.001	3	8
LUNG_SCLC	NOB1 →	+1.265	+1.246	<.001	<.001	3	6
LUNG_SCLC	THAP11 →	+0.447	+0.728	.004	.002	3	6
STOMACH	CIAO2B →	+0.514	+1.437	.001	<.001	3	5
BLOOD_Myeloma	NSUN6 →	+0.870	+1.473	.003	<.001	3	5
OESOPHAGUS	PLEKHA4 →	+2.026	+1.261	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031086 vs EDC4 — BLOOD_Leukemia

Explore this scatter interactively →