Post-embryonic camera-type eye development

pathway activity — cross-omics
GO:0031077Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Post-embryonic camera-type eye development pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CEP170_S359, CYRIB, and NAV1_S142, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACCEP170_S359 →-0.652-0.037.004.00836
HNSCCYRIB →-0.187-0.061<.001<.00134
LSCCNAV1_S142 →-0.698-0.062<.001<.00134
COADNIBAN2 →+0.235+0.051.002<.00134
GBMRBM47 →+0.423+0.076.002.00434
GBMTBX2_S386 →+0.421+0.092<.001<.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration