Pre-miRNA processing

Across TCGA patient cohorts, RNA activity of the Pre-miRNA processing pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C6orf132_S373, SLC27A4, and ERI3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pre-miRNA processing activity versus C6orf132_S373 in OV (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	C6orf132_S373 →	-1.112	-0.051	.001	.001	3	5
HNSC	SLC27A4 →	-0.422	-0.080	<.001	.001	3	5
BRCA	ERI3 →	+0.291	+0.027	.006	.005	3	5
UCEC	ABI2_S227 →	+0.476	+0.069	.005	.005	3	5
GBM	LMNA_S458 →	-0.364	-0.038	.001	.001	3	5
GBM	PIK3C2A_S259 →	-0.455	-0.046	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031054 vs C6orf132_S373 — OV

Explore this scatter interactively →