Pre-miRNA processing

Across TCGA patient cohorts, RNA activity of the Pre-miRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AURKB, PLK4, and MTFR2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pre-miRNA processing activity versus AURKB in LUAD (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AURKB →	+0.812	+0.543	<.001	<.001	3	6
LUAD	PLK4 →	+0.629	+0.611	<.001	<.001	3	5
PDAC	MTFR2 →	+0.440	+0.710	.001	.001	3	5
LUAD	CDC25C →	+0.619	+0.611	.001	.001	3	5
BRCA	CYP3A5 →	-0.241	-0.410	.003	.007	3	4
LUAD	CDC20 →	+0.939	+0.534	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031054 vs AURKB — LUAD

Explore this scatter interactively →