Pre-miRNA processing

Across TCGA cell cohorts, RNA activity of the Pre-miRNA processing pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAR, PRKRA, and AGO2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADAR grouped by Pre-miRNA processing-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ADAR →	-0.505	-0.401	.004	.003	3	9
LARGE_INTESTINE	PRKRA →	-0.340	-0.782	.001	<.001	3	7
BREAST	AGO2 →	-0.302	-1.066	<.001	<.001	3	6
OVARY	MCM4 →	-0.290	-0.786	.002	.009	2	5
BREAST	MEGF9 →	-0.160	-0.847	.003	.002	3	4
SKIN	RNF141 →	-0.633	-0.777	.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADAR by Pre-miRNA processing activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →