Pre-miRNA processing

Across TCGA cell cohorts, RNA activity of the Pre-miRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGO1, AGO3, and SFPQ, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pre-miRNA processing activity versus AGO1 in STOMACH (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	AGO1 →	+1.584	+0.149	<.001	<.001	3	19
BREAST	AGO3 →	+1.273	+0.114	<.001	<.001	3	18
STOMACH	SFPQ →	+0.945	+0.154	<.001	<.001	3	16
PANCREAS	PRDM2 →	+1.129	+0.088	<.001	<.001	3	16
STOMACH	AGO4 →	+1.750	+0.165	<.001	<.001	3	16
STOMACH	BRAF →	+0.971	+0.122	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031054 vs AGO1 — STOMACH

Explore this scatter interactively →