Pre-miRNA processing

Across TCGA cell cohorts, RNA activity of the Pre-miRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BYSL, LMNTD2, and NOXO1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pre-miRNA processing activity versus BYSL in OVARY (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	BYSL →	-0.957	-0.345	<.001	<.001	3	5
STOMACH	LMNTD2 →	+1.658	+0.251	<.001	.008	3	4
LARGE_INTESTINE	NOXO1 →	+1.558	+0.176	<.001	<.001	3	4
PANCREAS	POMT2 →	-0.811	-0.265	<.001	.008	3	4
LUNG_SCLC	CHMP4B →	+0.771	+0.286	.003	.002	3	4
LUNG_SCLC	ELMO3 →	+0.953	+0.281	.008	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031054 vs BYSL — OVARY

Explore this scatter interactively →