Myosin filament organization

Across TCGA cell cohorts, RNA activity of the Myosin filament organization pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NIBAN1, VAPA, and SLC16A10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NIBAN1 grouped by Myosin filament organization-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	NIBAN1 →	-2.826	-2.171	.004	<.001	3	5
PANCREAS	VAPA →	+0.715	+0.610	<.001	.002	3	4
LIVER	SLC16A10 →	+1.666	+1.460	<.001	.004	3	3
LIVER	INO80D →	+0.389	+1.683	.005	<.001	2	4
LIVER	KBTBD7 →	+0.738	+1.282	.002	.004	3	3
LIVER	MTHFS →	+0.890	+1.615	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NIBAN1 by Myosin filament organization activity — URINARY_TRACT

Explore this box plot interactively →