Myosin filament organization

Across TCGA cell cohorts, RNA activity of the Myosin filament organization pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF18, CDK17, and CCDC114, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myosin filament organization activity versus ARHGEF18 in BREAST (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ARHGEF18 →	+0.646	+0.717	<.001	.004	3	4
BONE	CDK17 →	+0.831	+0.227	.003	.001	3	3
STOMACH	CCDC114 →	+1.255	+0.280	.003	.001	3	3
STOMACH	RFC5 →	+1.001	+0.376	.005	<.001	3	3
STOMACH	CDK2 →	+0.752	+0.285	.001	.001	3	3
STOMACH	PPP1R16A →	-0.861	-0.291	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031033 vs ARHGEF18 — BREAST

Explore this scatter interactively →