Actomyosin structure organization

Across TCGA cell cohorts, RNA activity of the Actomyosin structure organization pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DOCK5, CRIM1, and S100A6, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actomyosin structure organization activity versus DOCK5 in OVARY (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DOCK5 →	+1.539	+0.330	.004	.008	3	9
OVARY	CRIM1 →	+3.160	+0.531	<.001	<.001	3	8
BREAST	S100A6 →	+2.580	+0.185	.001	.001	3	8
OVARY	PLEKHA2 →	+1.830	+0.330	<.001	.001	3	7
BLOOD_Lymphoma	CAST →	+1.497	+0.250	.003	.004	2	8
LUNG_NSCLC_LUSC	ETHE1 →	+1.527	+0.343	.002	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031032 vs DOCK5 — OVARY

Explore this scatter interactively →