Microtubule organizing center organization

Across TCGA cell cohorts, RNA activity of the Microtubule organizing center organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDC4, MPP5, and ARID3A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SDC4 grouped by Microtubule organizing center organization-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SDC4 →	+1.708	+0.169	.001	.001	3	4
SKIN	MPP5 →	+0.413	+0.214	.004	<.001	3	4
BLOOD_Leukemia	ARID3A →	+1.243	+0.164	.003	.008	3	4
BLOOD_Lymphoma	CEP68 →	-1.343	-0.229	.004	.006	3	4
SOFT_TISSUE	MARK3 →	+0.761	+0.169	.004	.002	3	4
SOFT_TISSUE	WDFY1 →	+1.122	+0.162	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SDC4 by Microtubule organizing center organization activity — BLOOD_Leukemia

Explore this box plot interactively →