Microtubule organizing center organization

Across TCGA cell cohorts, RNA activity of the Microtubule organizing center organization pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DKC1, PDCD5, and DDHD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule organizing center organization activity versus DKC1 in PANCREAS (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DKC1 →	-0.954	-0.236	.001	<.001	3	4
STOMACH	PDCD5 →	-1.078	-0.207	.003	.009	3	4
URINARY_TRACT	DDHD1 →	-1.103	-0.290	.007	.003	3	4
PANCREAS	NPM3 →	-0.750	-0.195	.007	.006	3	4
PANCREAS	HMGB3 →	-1.196	-0.229	.002	.001	3	4
OESOPHAGUS	MEPCE →	-0.775	-0.132	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031023 vs DKC1 — PANCREAS

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