Endocrine pancreas development

Across TCGA patient cohorts, RNA activity of the Endocrine pancreas development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are URB1, RNF5, and SHANK3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocrine pancreas development activity versus URB1 in BRCA (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	URB1 →	-0.241	-0.027	.002	.001	3	6
LSCC	RNF5 →	-0.324	-0.043	.002	.001	3	6
CCRCC	SHANK3 →	+0.392	+0.048	<.001	<.001	3	6
CCRCC	HSPA12B →	+0.292	+0.038	<.001	<.001	3	6
BRCA	MACROH2A1_T129 →	-0.469	-0.041	<.001	<.001	3	6
CCRCC	CNDP1 →	+0.384	+0.025	.006	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031018 vs URB1 — BRCA

Explore this scatter interactively →