Endocrine pancreas development

Across TCGA cell cohorts, RNA activity of the Endocrine pancreas development pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MDFI, DHX30, and ZNF689, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocrine pancreas development activity versus MDFI in PANCREAS (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MDFI →	+2.844	+0.999	.005	.008	3	4
PANCREAS	DHX30 →	-0.968	-1.259	<.001	<.001	3	4
SKIN	ZNF689 →	-2.017	-1.256	.003	.002	3	4
PANCREAS	ZNF594 →	-0.648	-1.043	.007	.007	3	4
PANCREAS	MAP4 →	-0.952	-1.108	<.001	.001	3	4
PANCREAS	FKBP5 →	-1.238	-1.052	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031018 vs MDFI — PANCREAS

Explore this scatter interactively →