Exocrine pancreas development

Across TCGA patient cohorts, RNA activity of the Exocrine pancreas development pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KANK2, DDX21_S121, and FERMT2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Exocrine pancreas development activity versus KANK2 in UCEC (Pearson r = 0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KANK2 →	+0.503	+0.122	<.001	<.001	3	8
CCRCC	DDX21_S121 →	-0.325	-0.076	<.001	<.001	3	7
UCEC	FERMT2 →	+0.438	+0.117	.004	.003	3	7
BRCA	TNS1_S445 →	+0.865	+0.122	<.001	<.001	3	7
GBM	UTRN →	+0.317	+0.056	<.001	.003	3	7
OV	LTV1 →	-0.445	-0.108	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031017 vs KANK2 — UCEC

Explore this scatter interactively →