Exocrine pancreas development

Across TCGA patient cohorts, RNA activity of the Exocrine pancreas development pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF13, DMAC2, and SLC13A5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Exocrine pancreas development activity versus KLF13 in GBM (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KLF13 →	-0.407	-0.126	<.001	<.001	3	4
LSCC	DMAC2 →	-0.309	-0.155	.001	.004	3	3
LSCC	SLC13A5 →	-0.440	-0.133	.006	.009	3	3
LUAD	CD79A →	-0.968	-0.177	.004	.002	3	3
LUAD	DUSP6 →	+0.559	+0.143	.001	<.001	3	3
LUAD	DEDD2 →	-0.362	-0.171	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031017 vs KLF13 — GBM

Explore this scatter interactively →