Endoplasmic reticulum unfolded protein response

Across TCGA patient cohorts, RNA activity of the Endoplasmic reticulum unfolded protein response pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN4_S432, CDC20_T106, and PLAC9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum unfolded protein response activity versus SEPTIN4_S432 in PDAC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SEPTIN4_S432 →	+0.434	+0.026	.001	<.001	3	6
COAD	CDC20_T106 →	-0.945	-0.020	.001	.002	3	6
BRCA	PLAC9 →	+0.389	+0.023	.003	.001	3	6
PDAC	RPS2 →	-0.185	-0.031	<.001	<.001	3	5
BRCA	THSD7A →	+0.525	+0.031	<.001	<.001	3	5
LSCC	TMOD2 →	+0.317	+0.039	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030968 vs SEPTIN4_S432 — PDAC

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