Endoplasmic reticulum unfolded protein response

Across TCGA cell cohorts, RNA activity of the Endoplasmic reticulum unfolded protein response pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYB561, TSPAN1, and ARHGEF10, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum unfolded protein response activity versus CYB561 in LIVER (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CYB561 →	+2.354	+0.253	.003	.005	3	8
BREAST	TSPAN1 →	+2.674	+0.205	<.001	<.001	3	7
LARGE_INTESTINE	ARHGEF10 →	-1.767	-0.202	.002	.001	3	6
PANCREAS	LRG1 →	+1.573	+0.155	<.001	.003	3	6
BREAST	TTL →	-1.176	-0.240	<.001	<.001	3	6
OVARY	TCF3 →	-0.956	-0.160	.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030968 vs CYB561 — LIVER

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