Positive regulation of vascular endothelial growth factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of vascular endothelial growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIAA1671-AS1, LAMC1, and COL6A3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vascular endothelial growth factor receptor signaling pathway activity versus KIAA1671-AS1 in HNSC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	KIAA1671-AS1 →	-0.721	-0.175	<.001	<.001	3	5
UCEC	LAMC1 →	+0.510	+0.693	.003	<.001	3	4
UCEC	COL6A3 →	+0.569	+0.632	.006	.002	3	4
BRCA	PXDN →	+0.614	+0.349	.002	.009	3	4
CCRCC	MYO1B →	+0.583	+0.557	.003	.009	3	4
CCRCC	VEGFC →	+0.512	+0.684	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030949 vs KIAA1671-AS1 — HNSC

Explore this scatter interactively →