Positive regulation of vascular endothelial growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of vascular endothelial growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM38, TIGD3, and NICN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vascular endothelial growth factor receptor signaling pathway activity versus TRIM38 in OESOPHAGUS (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TRIM38 →	-1.721	-1.166	<.001	.002	3	4
BLOOD_Leukemia	TIGD3 →	-0.548	-0.605	<.001	.003	3	4
BLOOD_Lymphoma	NICN1 →	+0.712	+0.684	.008	.009	3	4
OESOPHAGUS	SAMD12 →	-2.175	-0.915	<.001	.007	3	4
CNS	AP1S3 →	-0.792	-0.596	.003	.009	3	4
OESOPHAGUS	SYT8 →	-3.182	-1.011	.005	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030949 vs TRIM38 — OESOPHAGUS

Explore this scatter interactively →