Negative regulation of vascular endothelial growth factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of vascular endothelial growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOS, ZFP36, and ZDHHC23, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of vascular endothelial growth factor receptor signaling pathway activity versus FOS in CCRCC (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	FOS →	+1.155	+0.201	.002	.004	3	6
LSCC	ZFP36 →	+0.749	+0.147	.002	.001	3	5
COAD	ZDHHC23 →	-0.477	-0.281	<.001	<.001	3	4
UCEC	LURAP1L →	+0.903	+0.217	<.001	.001	2	5
CCRCC	DUSP1 →	+0.967	+0.196	.001	.006	3	4
HNSC	DAB2IP →	+0.495	+0.203	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030948 vs FOS — CCRCC

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