Negative regulation of vascular endothelial growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of vascular endothelial growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAT2, USP32, and RHBDF2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADAT2 grouped by Negative regulation of vascular endothelial growth factor receptor signaling pathway-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ADAT2 →	-0.661	-0.275	<.001	.005	3	3
LUNG_SCLC	USP32 →	-0.799	-0.299	.001	.005	3	3
STOMACH	RHBDF2 →	-1.083	-0.302	<.001	<.001	3	3
CNS	AADAT →	-0.705	-0.863	.009	.003	3	3
KIDNEY	RGS5 →	-1.197	-1.018	.004	.005	3	3
BREAST	SLC4A3 →	-0.945	-0.323	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADAT2 by Negative regulation of vascular endothelial growth factor receptor signaling pathway activity — STOMACH

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