Regulation of vascular endothelial growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of vascular endothelial growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF215, NHEJ1, and LOXL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF215 grouped by Regulation of vascular endothelial growth factor receptor signaling pathway-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ZNF215 →	-1.672	-1.774	.006	<.001	3	3
KIDNEY	NHEJ1 →	-0.453	-1.570	.008	<.001	3	3
PANCREAS	LOXL1 →	-1.303	-0.769	.003	.004	3	3
UPPER_AERODIGESTIVE_TRACT	CES3 →	+0.668	+0.887	.003	.005	3	3
UPPER_AERODIGESTIVE_TRACT	LDLRAD1 →	+0.552	+0.916	.001	.003	3	3
LARGE_INTESTINE	SPSB1 →	-1.250	-0.834	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF215 by Regulation of vascular endothelial growth factor receptor signaling pathway activity — BLOOD_Myeloma

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