Regulation of vascular endothelial growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of vascular endothelial growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RDH13, SERPINE1, and PGAP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vascular endothelial growth factor receptor signaling pathway activity versus RDH13 in SOFT_TISSUE (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RDH13 →	-1.038	-1.208	<.001	.003	3	4
LIVER	SERPINE1 →	+5.810	+0.626	.008	.006	3	4
OVARY	PGAP2 →	-0.993	-0.986	<.001	<.001	3	4
LUNG_SCLC	PTPN1 →	+0.900	+0.315	.002	<.001	2	5
LIVER	NOP2 →	-1.218	-0.533	.003	.006	3	4
BLOOD_Lymphoma	MRC2 →	+1.946	+0.380	.006	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030947 vs RDH13 — SOFT_TISSUE

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