Otic vesicle formation

Across TCGA patient cohorts, RNA activity of the Otic vesicle formation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CASP4, SOX9, and ITGB2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Otic vesicle formation activity versus CASP4 in GBM (Pearson r = -0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CASP4 →	-0.433	-0.057	.005	.002	3	6
LSCC	SOX9 →	+0.874	+0.090	<.001	<.001	3	6
OV	ITGB2 →	-0.622	-0.048	.001	.009	3	5
OV	ITSN2 →	-0.190	-0.046	.001	.001	3	5
HNSC	CASP10 →	-0.384	-0.074	.001	.003	3	5
HNSC	IFT74 →	+0.280	+0.106	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030916 vs CASP4 — GBM

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