Otic vesicle formation

Across TCGA patient cohorts, RNA activity of the Otic vesicle formation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PROX1, PROX1-AS1, and SOX9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Otic vesicle formation activity versus PROX1 in UCEC (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PROX1 →	+1.855	+0.820	<.001	.001	3	6
GBM	PROX1-AS1 →	+0.469	+0.438	<.001	<.001	3	6
BRCA	SOX9 →	+1.354	+0.359	<.001	<.001	3	4
HNSC	BEST3 →	+0.980	+0.665	<.001	<.001	3	4
LUAD	RRM2B →	-0.339	-0.609	.005	<.001	3	4
GBM	LINC00538 →	+0.496	+0.544	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030916 vs PROX1 — UCEC

Explore this scatter interactively →