Otic vesicle formation

Across TCGA cell cohorts, RNA activity of the Otic vesicle formation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGF10, SOX9, and CEP290, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FGF10 grouped by Otic vesicle formation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FGF10 →	-0.202	-0.762	<.001	<.001	3	7
LARGE_INTESTINE	SOX9 →	-0.348	-1.070	.001	.004	3	6
BREAST	CEP290 →	-0.358	-0.706	<.001	<.001	3	6
BLOOD_Leukemia	FGF8 →	-0.243	-1.625	<.001	<.001	3	5
CNS	CACNA1F →	+0.171	+1.415	<.001	<.001	3	5
SOFT_TISSUE	HSD17B1 →	-0.233	-1.365	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FGF10 by Otic vesicle formation activity — BREAST

Explore this box plot interactively →