Notochord development

Across TCGA patient cohorts, RNA activity of the Notochord development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COBL, SIRT3, and SBF2-AS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Notochord development activity versus COBL in UCEC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COBL →	+1.170	+0.753	<.001	.001	3	4
BRCA	SIRT3 →	+0.468	+0.482	.001	.008	2	5
BRCA	SBF2-AS1 →	+0.363	+0.572	.001	.009	3	4
LUAD	DDAH1 →	+0.590	+0.506	<.001	.002	3	4
LUAD	ESAM →	+0.498	+0.491	.006	.005	3	4
CCRCC	DRC3 →	+0.392	+0.541	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030903 vs COBL — UCEC

Explore this scatter interactively →