Notochord development

Across TCGA patient cohorts, RNA activity of the Notochord development pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COBL_S324, COBL_S347, and COBL_S235, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Notochord development activity versus COBL_S324 in CCRCC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	COBL_S324 →	+1.334	+0.986	<.001	<.001	3	4
HNSC	COBL_S347 →	+0.877	+1.110	<.001	<.001	3	4
BRCA	COBL_S235 →	+1.498	+0.924	.001	.002	3	4
OV	PDS5B_S1283 →	-0.942	-0.937	<.001	<.001	3	3
GBM	RFFL_S232 →	-0.742	-1.478	<.001	<.001	2	4
BRCA	COBL →	+0.625	+0.752	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030903 vs COBL_S324 — CCRCC

Explore this scatter interactively →